Be part of the battle against typhoid and paratyphoid A fever

Every year, it is estimated that there are 13 million cases of typhoid and paratyphoid A fever combined, resulting in 133 thousand deaths, mainly affecting school-aged children in Asia and Africa. We are looking for healthy volunteers to take part in a study to test a new vaccine against typhoid and paratyphoid A fever. In order to test if the vaccine works to protect against paratyphoid A fever, after vaccination with the new vaccine or a control vaccine, we will be challenging all participants with the bacteria that could cause paratyphoid fever. Participants will be treated with antibiotics as soon as they show symptoms of infection, or 14 days after drinking the bacteria even if they don’t have symptoms.

The study is being run by UHBW Vaccine & Testing Research Team, in collaboration with the Oxford Vaccine Group, and is funded by the Serum Institute of India.

If you are aged 18 to 55 years old, and in good health, you may be eligible to take part in the study. We will provide reimbursement for your time, inconvenience, and travel. Participants will receive up to £4410 if they remain in the study for the entire period and attend all the scheduled visits required for them. The total study participation time is 7 months, during this time you will be required to attend the NIHR Bristol Clinical Research Facility for all study visits and The Oxford Vaccine Group on challenge administration day (travel will be arranged for the challenge visit).

If you are interested in finding out more, please visit our website: https://www.ovg.ox.ac.uk/studies/bivista/bristol where you can access the Participant Information Sheet.

If you would like any further information regarding the study, please contact us on:

Email VaccineTestingResearch@uhbw.nhs.uk, Tel: 0117 342 1500